Iplathifomu Ebandakanya Konke Yokwakha, Ukudluliswa Kwezobuchwepheshe, kanye Nokukhiqiza Preclinical ku-cGMP Commercial: Ubuchwepheshe Nezinsizakalo
Amasistimu Wokulethwa Kwezidakamizwa (I-Lipids, Ama-Polymers, Ama-Hybrid)
Sakha Izinhlobonhlobo Zobambiswano Ngethimba Lethu Nobuchwepheshe, futhi Senza Izifundo Eziphelele Nezokuhlanganyela Ezihlanganisa Ucwaningo Olungokoqobo: Ukuthuthukiswa Kohlelo Lokulethwa Kwezidakamizwa ngama-API Afunwayo afana ne-mRNA, DNA, siRNA, Antibodies, Proteins, Peptides kanye namanye ama-Molecule Amancane: Characterization, kanye Izinsizakalo Zokuhlola, Inkampani Ebambisene Nentuthuko Esekelwe Uhulumeni (okungukuthi, SBIR/STTR)
Ukuhlolwa Kokuhlaziya, Ukwenziwa Kwezinhlamvu, Ukuthuthukiswa Kwe-Assay
Qedela Ukuhlola Ngokwezifiso Kokuhlaziya (i-GMP kanye Ne-Non-GMP) kanye Nezindlela Ezithuthukisiwe Zokuthuthukiswa Kwezidakamizwa, Ukuhlolwa Kokuhlaziya, Ukuthuthukiswa Nokudluliswa Kwezobuchwepheshe, Ukuthuthukiswa Kwephaneli Egcwele Yokuhlaziya kanye Nokuhlola Okufana: Usayizi We-Nanoparticle, Inkokhelo, Ukuphumelela Kwe-Ecapsulation, Ukuhlanzeka, I-Morphology, Okusele I-Solvent, I-Transition Temperature, Ukuhlola Okubonakalayo, kanye Ne-Microscopic.
Ukuthuthukiswa Kokwakhiwa Kwangaphambi Komtholampilo kanye namasampula
Izifundo ezinokwenzeka neziphelele, i-Nanoparticle Drug Delivery System Development (Preclinical Synthesis and Analytics), Kubandakanya i-Ionizable kanye neCationic Lipid Nanoparticles kanye ne-Polymeric kanye ne-Hybrid Lipid Nanoparticles, Ukuthuthukiswa, Ukuchazwa Kwezimilo, Ubuthi, Ukusebenza kahle, Izindlela Zokuhlaziya, Inqubo Yokuhlanganisa, Inqubo Yokwenza Izinto Ezincane I-Technology TransferPreclinical Formulation Synthesis, Ukuthuthukisa, Inqubo Yokukhiqiza, Amasistimu Okulethwa Kwezidakamizwa kanye Nokuthuthukiswa Kwezidakamizwa
Ukuthuthukiswa Kwenqubo Yokukhiqiza (GMP)
I-T&T Scientific Inikeza Okunhlobonhlobo futhi Eqinisweni zonke Izinqubo Zokukhiqiza Ezisetshenziselwa Ukukhiqiza Imikhiqizo Yezidakamizwa Ye-Nanoparticle Enjenge-Gene Therapies, kanye Nemigomo. Ukusho Okumbalwa Lezi zinqubo Kubandakanya: Umjovo we-Ethanol noma Umjovo we-Solvent, I-Thin Film Hydration, Extrusion, Homogenization, Microfluidics kanye ne-Sonication (Ukugeza, Ithiphu Nokuqhubekayo).
Ukuthuthukiswa Kwezindlela Zokuhlaziya (Iphaneli Eliphelele, Ukwakheka Kwezinhlamvu, Ukubika)
Kwa-T&T Scientific, Sinikeza Iphaneli Eliphelele neligcwele le-cGMP Analytical Panel Edingekayo Ukulawulwa Kwekhwalithi Yemikhiqizo Yezidakamizwa Ye-Nanoparticle efana: Usayizi We-Nanoparticle, Ukushaja, Ukusebenza Kwe-Ecapsulation, Ukuhlanzeka, I-Morphology, I-Residual Solvent, I-Transition Temperature, Ukuhlolwa Okubonakalayo, Ukukhomba kanye ne-Endosomal Properties kanye Microscopic. Siphinde Sisungule Ozakwethu Bezivivinyo Zomtholampilo Nezifundo Zezilwane.
cGMP Clinical and Commercial Batch Manufacturing, Gcwalisa futhi Qeda
I-T&T Scientific Iqedile Ukusebenza Kwe-GMP Ngaphansi Kophahla Olulodwa futhi Ihlolwe Ngempumelelo Izikhathi Ezingaphezu kwezi-5. I-T&T Scientific Corporation's Quality Management System ithatha isiqondiso ku-21 CFR Part 820 Quality System Regulations futhi ithobela zonke izimfuneko zokulawula ze-FDA GMP. Lezi zidingo zifaka 21 CFR Ingxenye 210, 21 CFR Ingxenye 211, kanye 21 CFR Ingxenye 11. Inkampani ayifuni ukukhishwa ku-21 CFR Ingxenye 820, 201, 211, 11 ku-7140 Regal Lane, Knoxville, TN 37918.
I-Solvent Injection Manufacturing Technologies
I-Solvent Injection Technologies Umjovo Wesixazululo Se-Lipid (Ku-Ethanol Noma I-Diethyl Ether) Ku-Aqueous Medium Kubandakanya Isidakamizwa kanye Nesibhafa. Izindlela Zokujova I-Solvent Zihlanganisa Ukuncibilika Kwe-Lipid Kuyi-Organic Solvent Nokujova Isixazululo Esigabeni Esimanzi. Izincibilikisi Ezimbili Eziyinhloko (i-Ethanol Ne-Ether) Ziye Zaqashwa Ukulungiselela I-Liposomal Nanoformulation. I-T&T Scientific Inikeza Inkundla Engcono Kakhulu Yomhlaba Ye-Scalable, GMP, Controlled and Precise Production ye-Nanoparticle Drug Products ngesinyathelo esisodwa.
I-Liposome Extrusion Manufacturing Technologies
Amasu e-Liposome Extrusion Asetshenziselwa Ukulinganisa Ngokuqondile I-Lipid Nanoparticles, i-Liposomes, i-Lipoplexes, i-Niosomes kanye Neminye Imikhiqizo Yezidakamizwa Ye-Nano-scale kanye Nezinhlelo Zokulethwa Kwezidakamizwa. I-T&T Scientific Inikezela Ngohlelo Lokuqala Lokusebenzisa Okukodwa Emhlabeni I-Lipid kanye ne-Liposome Extrusion System Evumela Ukukhiqizwa Okusheshayo, Okulula, Okungangcolisi, kanye Nekhwalithi Ephezulu Yale Mikhiqizo Yezidakamizwa Ye-Nanomedicine ene-PDI ephansi njengo-0.05-0.07
Amasistimu Wokulethwa Kwezidakamizwa (I-Lipids, i-Polymer, i-Hybrid)
I-T&T Scientific Inikeza Kokubili:
1) Imikhiqizo elungele ukusetshenziswa namakhithi njengama-lipids, ama-Polymers nama-Hybrid Nanoparticles
I-2) Ngaphansi Kokuthuthukiswa Nokulinganisa I-Nanoparticles Eyenziwe I-Lipids (i-Cationic, Ionizable, ne-Neutral), i-Polymers, ne-Hybrid ehlanganisa Izinhlobo Ezihlukene ze-Lipids nama-Polymers.
Funda Ngentuthuko Yakamuva Enomthelela Embonini Nezemfundo
I-Taylor Dispersion Analysis ukusekela ukwakheka kwe-lipid-nanoparticle emithini yokugoma ye-mRNA
I-Lipid nanoparticles (LNPs) njengamanje ayizinhlelo zokulethwa kwe-messenger ribonucleic acid (mRNA) ezithuthuke kakhulu ezingezona igciwane.
Funda kabanzi
Ukusatshalaliswa komthwalo wenkokhelo namandla we-mRNA lipid nanoparticles
I-Lipid nanoparticles (LNPs) izimoto ezisebenzayo zokuletha imigomo ye-mRNA kanye nokwelapha. Kube yinselele ukuhlola izici zokupakisha ze-mRNA.....
Funda kabanzi
I-RNA eyindilinga: Umngcele osafufusa ekuhlosweni kwe-RNA zokwelapha, ukwelashwa kwe-RNA, nemithi yokugomela ye-mRNA
Ama-RNA ayindilinga (circRNA) ikilasi lemvelo (biogenic) noma i-RNA yokwenziwa evaliwe ngaphandle kweziphetho ezi-5′ noma ezi-3......
Funda kabanzi
Funda Ngentuthuko Yakamuva Enomthelela Embonini Nezemfundo
Ukufakwa okugcwele kwegciwane le-oncolytic kusetshenziswa i-hybrid erythroctye-liposome membranes ukuze kube nokusebenza okuthuthukisiwe kwe-anti-refractory tumor.
Ukulethwa nge-intravenous kwe-oncolytic virus (OVs) kuyathembisa ekwelashweni komdlavuza.
Funda kabanzi
Izindlela zokuzivikela ezizalwa nazo zemithi yokugoma ye-mRNA
Inkundla ye-lipid nanoparticle (LNP)-encapsulated, i-nucleoside-modified mRNA isetshenziselwe ukukhiqiza imigomo ephephile nesebenzayo ngesikhathi esirekhodiwe ngokumelene ne-COVID-19.
Funda kabanzi
Umuthi wokugomela i-RNA ozikhulisayo uvikela amagundane ekuthelelekeni ngegciwane le-Ebola elibulalayo
Amagciwane asafufusa navela kabusha, njenge-Zaire Ebola virus (EBOV), ayingozi emhlabeni wonke futhi adinga izinyathelo zokulwa ngokushesha....
Funda kabanzi
Sebenzisa imicibisholo yesokunxele / kwesokudla ukuhamba ngesilayidi yesilayidi noma swayiphela ngakwesokunxele / kwesokudla uma usebenzisa idivayisi yeselula
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