I-Platform Ehlanganisa Konke Yezinsizakalo Nobuchwepheshe Efakazelwe kanye
Ubuchwepheshe obunezimpande ezijulile ku-Nanoparticle-Isekelwe
Imikhiqizo yezidakamizwa (LNPs, PNPs, and Hybrid) evela
Ukwakhiwa Kwangaphambi Kokwelashwa Kwe-cGMP Manufacturing
I-T&T Scientific's Electronic Quality Management System (eQMS)
Iqondiswa yimithethonqubo ye-FDA 21 CFR Ingxenye 820 futhi Iyathotshelwa
Yonke i-FDA 21 CFR Ingxenye 210, 21 CFR Ingxenye 211, kanye 21 CFR Ingxenye 11 Regulations
I-Nanoparticle Pharmaceutical Manufacturing Technology Platform Edidiyelwe Ngokugcwele futhi Ezenzakalelayo:Iyakala futhi Iyaqhubekayo, Isebenzisa Ukufunda Ngomshini Nokwenziwa Ngokwenziwa.
Ubuhlakani Ekukhiqizeni Imithi:
mLs to 100s of L's | Izindleko Eziphansi | Ukusebenza Okuphezulu | Small Foot-Print NanoSizer FLOWTM Technologies

Amasistimu Wokulethwa Kwezidakamizwa (I-Lipids, Ama-Polymers, Ama-Hybrid)
Sakha Izinhlobonhlobo Zobambiswano Ngethimba Lethu Nobuchwepheshe, futhi Senza Izifundo Eziphelele Nezokuhlanganyela Ezihlanganisa Ucwaningo Olungokoqobo: Ukuthuthukiswa Kohlelo Lokulethwa Kwezidakamizwa ngama-API Afunwayo afana ne-mRNA, DNA, siRNA, Antibodies, Proteins, Peptides kanye namanye ama-Molecule Amancane: Characterization, kanye Izinsizakalo Zokuhlola, Inkampani Ebambisene Nentuthuko Esekelwe Uhulumeni (okungukuthi, SBIR/STTR)

Ukuhlolwa Kokuhlaziya, Ukwenziwa Kwezinhlamvu, Ukuthuthukiswa Kwe-Assay
Qedela Ukuhlola Ngokwezifiso Kokuhlaziya (i-GMP kanye Ne-Non-GMP) kanye Nezindlela Ezithuthukisiwe Zokuthuthukiswa Kwezidakamizwa, Ukuhlolwa Kokuhlaziya, Ukuthuthukiswa Nokudluliswa Kwezobuchwepheshe, Ukuthuthukiswa Kwephaneli Egcwele Yokuhlaziya kanye Nokuhlola Okufana: Usayizi We-Nanoparticle, Inkokhelo, Ukuphumelela Kwe-Ecapsulation, Ukuhlanzeka, I-Morphology, Okusele I-Solvent, I-Transition Temperature, Ukuhlola Okubonakalayo, kanye Ne-Microscopic.

Ukuthuthukiswa Kokwakhiwa Kwangaphambi Komtholampilo kanye namasampula
Izifundo ezinokwenzeka neziphelele, i-Nanoparticle Drug Delivery System Development (Preclinical Synthesis and Analytics), Kubandakanya i-Ionizable kanye neCationic Lipid Nanoparticles kanye ne-Polymeric kanye ne-Hybrid Lipid Nanoparticles, Ukuthuthukiswa, Ukuchazwa Kwezimilo, Ubuthi, Ukusebenza kahle, Izindlela Zokuhlaziya, Inqubo Yokuhlanganisa, Inqubo Yokwenza Izinto Ezincane I-Technology TransferPreclinical Formulation Synthesis, Ukuthuthukisa, Inqubo Yokukhiqiza, Amasistimu Okulethwa Kwezidakamizwa kanye Nokuthuthukiswa Kwezidakamizwa

Ukuthuthukiswa Kwenqubo Yokukhiqiza (GMP)
I-T&T Scientific Inikeza Okunhlobonhlobo futhi Eqinisweni zonke Izinqubo Zokukhiqiza Ezisetshenziselwa Ukukhiqiza Imikhiqizo Yezidakamizwa Ye-Nanoparticle Enjenge-Gene Therapies, kanye Nemigomo. Ukusho Okumbalwa Lezi zinqubo Kubandakanya: Umjovo we-Ethanol noma Umjovo we-Solvent, I-Thin Film Hydration, Extrusion, Homogenization, Microfluidics kanye ne-Sonication (Ukugeza, Ithiphu Nokuqhubekayo).

Ukuthuthukiswa Kwezindlela Zokuhlaziya (Iphaneli Eliphelele, Ukwakheka Kwezinhlamvu, Ukubika)
Kwa-T&T Scientific, Sinikeza Iphaneli Eliphelele neligcwele le-cGMP Analytical Panel Edingekayo Ukulawulwa Kwekhwalithi Yemikhiqizo Yezidakamizwa Ye-Nanoparticle efana: Usayizi We-Nanoparticle, Ukushaja, Ukusebenza Kwe-Ecapsulation, Ukuhlanzeka, I-Morphology, I-Residual Solvent, I-Transition Temperature, Ukuhlolwa Okubonakalayo, Ukukhomba kanye ne-Endosomal Properties kanye Microscopic. Siphinde Sisungule Ozakwethu Bezivivinyo Zomtholampilo Nezifundo Zezilwane.

cGMP Clinical and Commercial Batch Manufacturing, Gcwalisa futhi Qeda
I-T&T Scientific Iqedile Ukusebenza Kwe-GMP Ngaphansi Kophahla Olulodwa futhi Ihlolwe Ngempumelelo Izikhathi Ezingaphezu kwezi-5. I-T&T Scientific Corporation's Quality Management System ithatha isiqondiso ku-21 CFR Part 820 Quality System Regulations futhi ithobela zonke izimfuneko zokulawula ze-FDA GMP. Lezi zidingo zifaka 21 CFR Ingxenye 210, 21 CFR Ingxenye 211, kanye 21 CFR Ingxenye 11. Inkampani ayifuni ukukhishwa ku-21 CFR Ingxenye 820, 201, 211, 11 ku-7140 Regal Lane, Knoxville, TN 37918.

I-Solvent Injection Manufacturing Technologies
I-Solvent Injection Technologies Umjovo Wesixazululo Se-Lipid (Ku-Ethanol Noma I-Diethyl Ether) Ku-Aqueous Medium Kubandakanya Isidakamizwa kanye Nesibhafa. Izindlela Zokujova I-Solvent Zihlanganisa Ukuncibilika Kwe-Lipid Kuyi-Organic Solvent Nokujova Isixazululo Esigabeni Esimanzi. Izincibilikisi Ezimbili Eziyinhloko (i-Ethanol Ne-Ether) Ziye Zaqashwa Ukulungiselela I-Liposomal Nanoformulation. I-T&T Scientific Inikeza Inkundla Engcono Kakhulu Yomhlaba Ye-Scalable, GMP, Controlled and Precise Production ye-Nanoparticle Drug Products ngesinyathelo esisodwa.

I-Liposome Extrusion Manufacturing Technologies
Amasu e-Liposome Extrusion Asetshenziselwa Ukulinganisa Ngokuqondile I-Lipid Nanoparticles, i-Liposomes, i-Lipoplexes, i-Niosomes kanye Neminye Imikhiqizo Yezidakamizwa Ye-Nano-scale kanye Nezinhlelo Zokulethwa Kwezidakamizwa. I-T&T Scientific Inikezela Ngohlelo Lokuqala Lokusebenzisa Okukodwa Emhlabeni I-Lipid kanye ne-Liposome Extrusion System Evumela Ukukhiqizwa Okusheshayo, Okulula, Okungangcolisi, kanye Nekhwalithi Ephezulu Yale Mikhiqizo Yezidakamizwa Ye-Nanomedicine ene-PDI ephansi njengo-0.05-0.07

Amasistimu Wokulethwa Kwezidakamizwa (I-Lipids, i-Polymer, i-Hybrid)
I-T&T Scientific Inikeza Kokubili:
1) Imikhiqizo elungele ukusetshenziswa namakhithi njengama-lipids, ama-Polymers nama-Hybrid Nanoparticles
I-2) Ngaphansi Kokuthuthukiswa Nokulinganisa I-Nanoparticles Eyenziwe I-Lipids (i-Cationic, Ionizable, ne-Neutral), i-Polymers, ne-Hybrid ehlanganisa Izinhlobo Ezihlukene ze-Lipids nama-Polymers.
Yonke Ingxenyekazi Yenkundla Yokuthuthukiswa Kwenkontileka Yensizakalo kanye Nenhlangano Yezokukhiqiza (CDMO)
Yonke Ingxenyekazi Yenkundla Yokuthuthukiswa Kwenkontileka Yensizakalo kanye Nenhlangano Yezokukhiqiza (CDMO)
Ihambisana Nemithethonqubo ye-FDA 21 CFR Ingxenye 820, FDA 21 CFR Ingxenye 210, 21 CFR Ingxenye 211, kanye 21 CFR Ingxenye 11 Regulations
I-Nanoparticle Drug Products Manufacturing Technology Platform Edidiyelwe Ngokugcwele
:Okunwebekayo futhi Okuqhubekayo:
mLs ukuya ku-100s of L's Batch sizes

Amasistimu Wokulethwa Kwezidakamizwa (I-Lipids, Ama-Polymers, Ama-Hybrid)
Sakha Izinhlobonhlobo Zobambiswano Ngethimba Lethu Nobuchwepheshe, futhi Senza Izifundo Eziphelele Nezokuhlanganyela Ezihlanganisa Ucwaningo Olungokoqobo: Ukuthuthukiswa Kohlelo Lokulethwa Kwezidakamizwa ngama-API Afunwayo afana ne-mRNA, DNA, siRNA, Antibodies, Proteins, Peptides kanye namanye ama-Molecule Amancane: Characterization, kanye Izinsizakalo Zokuhlola, Inkampani Ebambisene Nentuthuko Esekelwe Uhulumeni (okungukuthi, SBIR/STTR)

Ukuhlolwa Kokuhlaziya, Ukwenziwa Kwezinhlamvu, Ukuthuthukiswa Kwe-Assay
Qedela Ukuhlola Ngokwezifiso Kokuhlaziya (i-GMP kanye Ne-Non-GMP) kanye Nezindlela Ezithuthukisiwe Zokuthuthukiswa Kwezidakamizwa, Ukuhlolwa Kokuhlaziya, Ukuthuthukiswa Nokudluliswa Kwezobuchwepheshe, Ukuthuthukiswa Kwephaneli Egcwele Yokuhlaziya kanye Nokuhlola Okufana: Usayizi We-Nanoparticle, Inkokhelo, Ukuphumelela Kwe-Ecapsulation, Ukuhlanzeka, I-Morphology, Okusele I-Solvent, I-Transition Temperature, Ukuhlola Okubonakalayo, kanye Ne-Microscopic.

Ukuthuthukiswa Kokwakhiwa Kwangaphambi Komtholampilo kanye namasampula
Izifundo ezinokwenzeka neziphelele, i-Nanoparticle Drug Delivery System Development (Preclinical Synthesis and Analytics), Kubandakanya i-Ionizable kanye neCationic Lipid Nanoparticles kanye ne-Polymeric kanye ne-Hybrid Lipid Nanoparticles, Ukuthuthukiswa, Ukuchazwa Kwezimilo, Ubuthi, Ukusebenza kahle, Izindlela Zokuhlaziya, Inqubo Yokuhlanganisa, Inqubo Yokwenza Izinto Ezincane I-Technology TransferPreclinical Formulation Synthesis, Ukuthuthukisa, Inqubo Yokukhiqiza, Amasistimu Okulethwa Kwezidakamizwa kanye Nokuthuthukiswa Kwezidakamizwa

Amasistimu Wokulethwa Kwezidakamizwa (I-Lipids, Ama-Polymers, Ama-Hybrid)
Sakha Izinhlobonhlobo Zobambiswano Ngethimba Lethu Nobuchwepheshe, futhi Senza Izifundo Eziphelele Nezokuhlanganyela Ezihlanganisa Ucwaningo Olungokoqobo: Ukuthuthukiswa Kohlelo Lokulethwa Kwezidakamizwa ngama-API Afunwayo afana ne-mRNA, DNA, siRNA, Antibodies, Proteins, Peptides kanye namanye ama-Molecule Amancane: Characterization, kanye Izinsizakalo Zokuhlola, Inkampani Ebambisene Nentuthuko Esekelwe Uhulumeni (okungukuthi, SBIR/STTR)

Ukuhlolwa Kokuhlaziya, Ukwenziwa Kwezinhlamvu, Ukuthuthukiswa Kwe-Assay
Qedela Ukuhlola Ngokwezifiso Kokuhlaziya (i-GMP kanye Ne-Non-GMP) kanye Nezindlela Ezithuthukisiwe Zokuthuthukiswa Kwezidakamizwa, Ukuhlolwa Kokuhlaziya, Ukuthuthukiswa Nokudluliswa Kwezobuchwepheshe, Ukuthuthukiswa Kwephaneli Egcwele Yokuhlaziya kanye Nokuhlola Okufana: Usayizi We-Nanoparticle, Inkokhelo, Ukuphumelela Kwe-Ecapsulation, Ukuhlanzeka, I-Morphology, Okusele I-Solvent, I-Transition Temperature, Ukuhlola Okubonakalayo, kanye Ne-Microscopic.

Ukuthuthukiswa Kokwakhiwa Kwangaphambi Komtholampilo kanye namasampula
Izifundo ezinokwenzeka neziphelele, i-Nanoparticle Drug Delivery System Development (Preclinical Synthesis and Analytics), Kubandakanya i-Ionizable kanye neCationic Lipid Nanoparticles kanye ne-Polymeric kanye ne-Hybrid Lipid Nanoparticles, Ukuthuthukiswa, Ukuchazwa Kwezimilo, Ubuthi, Ukusebenza kahle, Izindlela Zokuhlaziya, Inqubo Yokuhlanganisa, Inqubo Yokwenza Izinto Ezincane I-Technology TransferPreclinical Formulation Synthesis, Ukuthuthukisa, Inqubo Yokukhiqiza, Amasistimu Okulethwa Kwezidakamizwa kanye Nokuthuthukiswa Kwezidakamizwa

Amasistimu Wokulethwa Kwezidakamizwa (I-Lipids, Ama-Polymers, Ama-Hybrid)
Sakha Izinhlobonhlobo Zobambiswano Ngethimba Lethu Nobuchwepheshe, futhi Senza Izifundo Eziphelele Nezokuhlanganyela Ezihlanganisa Ucwaningo Olungokoqobo: Ukuthuthukiswa Kohlelo Lokulethwa Kwezidakamizwa ngama-API Afunwayo afana ne-mRNA, DNA, siRNA, Antibodies, Proteins, Peptides kanye namanye ama-Molecule Amancane: Characterization, kanye Izinsizakalo Zokuhlola, Inkampani Ebambisene Nentuthuko Esekelwe Uhulumeni (okungukuthi, SBIR/STTR)

Ukuhlolwa Kokuhlaziya, Ukwenziwa Kwezinhlamvu, Ukuthuthukiswa Kwe-Assay
Qedela Ukuhlola Ngokwezifiso Kokuhlaziya (i-GMP kanye Ne-Non-GMP) kanye Nezindlela Ezithuthukisiwe Zokuthuthukiswa Kwezidakamizwa, Ukuhlolwa Kokuhlaziya, Ukuthuthukiswa Nokudluliswa Kwezobuchwepheshe, Ukuthuthukiswa Kwephaneli Egcwele Yokuhlaziya kanye Nokuhlola Okufana: Usayizi We-Nanoparticle, Inkokhelo, Ukuphumelela Kwe-Ecapsulation, Ukuhlanzeka, I-Morphology, Okusele I-Solvent, I-Transition Temperature, Ukuhlola Okubonakalayo, kanye Ne-Microscopic.

Ukuthuthukiswa Kokwakhiwa Kwangaphambi Komtholampilo kanye namasampula
Izifundo ezinokwenzeka neziphelele, i-Nanoparticle Drug Delivery System Development (Preclinical Synthesis and Analytics), Kubandakanya i-Ionizable kanye neCationic Lipid Nanoparticles kanye ne-Polymeric kanye ne-Hybrid Lipid Nanoparticles, Ukuthuthukiswa, Ukuchazwa Kwezimilo, Ubuthi, Ukusebenza kahle, Izindlela Zokuhlaziya, Inqubo Yokuhlanganisa, Inqubo Yokwenza Izinto Ezincane I-Technology TransferPreclinical Formulation Synthesis, Ukuthuthukisa, Inqubo Yokukhiqiza, Amasistimu Okulethwa Kwezidakamizwa kanye Nokuthuthukiswa Kwezidakamizwa
I-T&T Scientific iyiPlathifomu Yezinkonzo Nobuchwepheshe Ehlanganisa Konke Ngokugxila Ekwakheni nasekukhiqizeni Imikhiqizo Yezidakamizwa Esekelwe ku-Biopharmaceutical Nanoparticle-based and Manufacturing.
Inkundla Yethu Yokukhiqiza E-Scalable, Yekhwalithi Ephezulu, kanye Nezindleko Eziphansi Ikhiqiza Imithi Yokwelapha Enembile, Esezingeni Eliphezulu, kanye Nemithi Yokwelapha Elawulwa Ikhwalithi kanye Nemigomo
Izinsiza Zethu Zihlanganisa Ukwakhiwa, Ukuthuthukisa, kanye Nokwenziwa Kwe-cGMP Kwemithi Ye-Nanomedicine kanye Nokwelapha Ngezakhi Zofuzo kusukela ku-Preclinical kuya ku-Commerce Stages With Various APIs Ukukala kusuka ku-Microliters kuya ngaphezu kwe-100 Liter Batches.
I-T&T Scientific Isungule Amaklayenti Nobambiswano Emazweni angaphezu kuka-50, Ngesiko Lokuthuthukisa Ithalente Elimaphakathi neKhasimende Nezemfundo ukuze Idale Ngokuphumelelayo Iplathifomu Yezokwelapha Ehlanganisa Konke Ehlanganisa Konke Neyokuhumusha.

Amasistimu Wokulethwa Okusekelwe ku-Lipid Ekuthuthukisweni Kwemithi Yofuzo kanye ne-Subunit
Abathwali be-lipidic bakhiwe ngezinto zemvelo, zokwenziwa, noma ze-physiological lipid/phospholipid.

Ukuthuthukiswa kwezimo zokugcina zemithi yokugomela i-lipid nanoparticle-formuated self-replicating RNA
Olunye ucwaningo lokuqala ekulethweni kwama-molecule e-RNA luhlehlela emuva ku-1978, lapho ama-lymphocyte egundane adluliselwa ku-vitro nge-mRNA encoding rabbit globin kusetshenziswa ama-liposomes.

Ububanzi nezinselelo zokulethwa kwe-mRNA esekwe ku-nanoparticle ekwelashweni komdlavuza
I-mRNA inenkulumo ehlukile nedlulayo eyehlisa ubungozi bokufakwa kwe-mutagenesis. Selokhu kwatholakala i-in vitro ebhalwe ukuthi i-mRNA, i-mRNA yokwenziwa izuze isithakazelo esikhulu kososayensi abahlukene besayensi yezinto eziphilayo, ezokwelapha, nesayensi.

I-Taylor Dispersion Analysis ukusekela ukwakheka kwe-lipid-nanoparticle emithini yokugoma ye-mRNA
I-Lipid nanoparticles (LNPs) njengamanje ayizinhlelo zokulethwa kwe-messenger ribonucleic acid (mRNA) ezithuthuke kakhulu ezingezona igciwane.

Ukusatshalaliswa komthwalo wenkokhelo namandla we-mRNA lipid nanoparticles
I-Lipid nanoparticles (LNPs) izimoto ezisebenzayo zokuletha imigomo ye-mRNA kanye nokwelapha. Kube yinselele ukuhlola izici zokupakisha ze-mRNA.....

I-RNA eyindilinga: Umngcele osafufusa ekuhlosweni kwe-RNA zokwelapha, ukwelashwa kwe-RNA, nemithi yokugomela ye-mRNA
Ama-RNA ayindilinga (circRNA) ikilasi lemvelo (biogenic) noma i-RNA yokwenziwa evaliwe ngaphandle kweziphetho ezi-5′ noma ezi-3......

Ukufakwa okugcwele kwegciwane le-oncolytic kusetshenziswa i-hybrid erythroctye-liposome membranes ukuze kube nokusebenza okuthuthukisiwe kwe-anti-refractory tumor.
I-Lipid nanoparticles (LNPs) njengamanje ayizinhlelo zokulethwa kwe-messenger ribonucleic acid (mRNA) ezithuthuke kakhulu ezingezona igciwane.

Izindlela zokuzivikela ezizalwa nazo zemithi yokugoma ye-mRNA
Izikhala ezibalulekile ekuqondeni nasekuxoxisaneni ukuthi ukuqonda okusha kwezinqubo ezingaphansi kokusebenza kwemithi yokugomela i-mRNA-LNP kungavumela kanjani ukuhlanganisa i-mRNA nama-molecule enkampani yenethiwekhi.

I-Lipid Nanoparticles─Kusuka ku-Liposomes kuya ku-mRNA Vaccine Delivery, Indawo Yokuhlukahluka Kocwaningo kanye Nentuthuko
Umthelela wama-anti-PEG amasosha omzimba odalwe imijovo ye-SARS-CoV-2 mRNA

Kungani ukwakheka kwe-mRNA-ionizable LNPs kuhlala isikhathi esifushane: izimbangela kanye nendlela yokuphuma
Ngokuhamba kwesikhathi, inani elincane le-ethanol lehlisa ulwelwesi lwe-lipid, okwenza ukwakheka kungazinzi.

Albert Einstein
I-physicist
"Umcabango ubaluleke kakhulu kunolwazi. Ulwazi lulinganiselwe. Umcabango uzungeza umhlaba.... Okubalulekile ukuthi ungayeki ukubuza. Ilukuluku linesizathu salo sokuba khona.... Impilo ifana nokugibela ibhayisikili. Ukugcina ibhalansi, kufanele uqhubeke uhamba.... Lwela ukuba ungabi yimpumelelo, kodwa kunalokho ube yigugu....."

Thomas Edison
Inventor
"Ungalokothi udikibale uma wehluleka. Funda kukho. Qhubeka uzame.... Angehlulekile. Ngisanda kuthola izindlela eziwu-10,000 ezingeke zisebenze.... Ukungahlaliseki kungukungeneliseki nokunganeliseki kuyisidingo sokuqala senqubekela phambili. .Ngibonise indoda egculisekile ngizokukhombisa isehluleki."

Bob Langer
MIT - Harvard
"Khuthaza abafundi ukuthi basebenze kumaphrojekthi anethonya eliphezulu angashintsha umhlaba. Ungalokothi uthi lo mbono awukwazi ukusebenza. Vele ulandele inhliziyo yakho. Khetha okuthile ocabanga ukuthi uzokuthanda. Bengizama ukuthuthukisa i-polymer ekhishwayo elawulwayo kanye nezinto zazingasebenzi kahle. Kwakunamakhulu ezindlela zokucabanga ngokwenza lokhu... Ingqondo yami yangisiza yangiholela endleleni esebenzayo."

Steve Jobs
Apple
"Abantu bacabanga ukuthi ukugxila kusho ukuthi yebo entweni okufanele ugxile kuyo.... Kusho ukuthi cha kweyikhulu eminye imibono emihle ekhona. Kumele ukhethe ngokucophelela. Ungavumeli umsindo wabanye" imibono iqeda izwi lakho elingaphakathi... Kwesinye isikhathi impilo ikushaya ekhanda ngesitini ungalahli ukholo..... Akukona ukukholwa kwezobuchwepheshe. Ukukholwa kubantu.

Jack Ma
Alibaba Group
"Uma ungayeki, usenethuba. Ukuyeka kungukufeyila okukhulu kakhulu. Ngehlulekile izinto ezihlekisayo: ukuhlolwa okubalulekile esikoleni samabanga aphansi izikhathi ezimbili, kathathu esikoleni esiphakathi, ngafaka isicelo se-Harvard, izikhathi ezingu-10. , yenqatshwa, ngafaka isicelo se-KFC ifika eChina, kwafika abantu abangu-24 befuna umsebenzi, abangu-23 bawuthola, yimi ngedwa ongawutholanga.”

Jeff Bezos
Amazon
"Uma singagcina izimbangi zethu zigxile kithi ngenkathi sihlala sigxile ekhasimendeni, ekugcineni sizohamba kahle.... Okuyingozi ukungaguquki. I-Amazon iyindawo engcono kakhulu emhlabeni yokuhluleka... indawo engcono kakhulu emhlabeni yokwehluleka nokwehluleka kanye nokusungulwa amawele angenakuhlukaniswa.Izinkampani ezingaqhubeki nokuzama noma ukwamukela ukwehluleka ekugcineni zifika esimeni lapho okuwukuphela kwento ezingayenza ukubheja uHail Mary ekupheleni ubukhona benkampani."